تفاعل #417970

معادلة التفاعل

Acetic acid

25b

1-bromo-4-nitro-2-(2-phenoxy-ethoxy)-benzene

→

aniline

المردود 84.0%

4-bromo-3-(2-phenoxy-ethoxy)-phenylamine

المردود 84.0%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe mixture was filtered
2. 2
   workup.DISTILLATIONthe solvent distilled off under reduced pressure
3. 3
   أخرىthe crude was purified by flash column chromatography

الإجراء التجريبي

Acetic acid (1.068 mL, 18 mmol) was added to the mixture of 25b (600 mg, 1.8 mmol) and zinc dust (1.157 g, 18.0 mmol) in ethanol (10 mL) at 0° C. The reaction mixture was warmed to room temperature and stirred for 4 hrs. The mixture was filtered, the solvent distilled off under reduced pressure and the crude was purified by flash column chromatography to obtain the aniline 25c in 84% yield.

المصدر