تفاعل #417964

معادلة التفاعل

Acetic anhydride

4-chloro-3-hydroxy aniline

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product 17a

المردود 93.0%

N-(4-chloro-3-hydroxyphenyl)acetamide

المردود 93.0%

المذيبات

acetic acid

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthe reaction was refluxed for 5 mins
2. 2
   ترشيحIt was filtered off
3. 3
   غسيلwashed with water (10 mL)
4. 4
   أخرىdried

الإجراء التجريبي

Acetic anhydride (3.0 mL, 42.0 mmol) was added to a solution of 4-chloro-3-hydroxy aniline (4.0 g, 28 mmol) in acetic acid (20 mL), and the reaction was refluxed for 5 mins. The reaction mixture was cooled to room temperature and the product was solidified. It was filtered off and washed with water (10 mL) and dried to obtain the product 17a in 93% yield (4.8 g) as a creamy white solid. There was no need for further purification.

المصدر