تفاعل #417952

معادلة التفاعل

dimethyl sulfone

sodium-bis-(trimethylsilyl)-amide

THF

2-bromo-6-fluoropyridine

→

2-Bromo-6-(1-methanesulfonyl-cyclopropyl)-pyridine

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction is quenched by the addition
2. 2
   استخلاصNaCl solution and extracted with EtOAc
3. 3
   تجفيفThe organic layer is dried over MgSO4
4. 4
   ترشيحfiltered
5. 5
   أخرىthe solvent is removed in vacuo

الإجراء التجريبي

Under inert gas atmosphere 28.4 mL (56.8 mmol) of a sodium-bis-(trimethylsilyl)-amide solution in THF (c=2 mol/L) are chilled to −17° C. and dropwise charged with 2.00 g (11.3 mmol) 2-bromo-6-fluoropyridine. Afterwards 2.14 g (22.7 mmol) dimethyl sulfone are added and the reaction mixture is stirred at −17° C. for 1 h. The reaction is quenched by the addition of aq. sat.NaCl solution and extracted with EtOAc. The organic layer is dried over MgSO4, filtered and the solvent is removed in vacuo.

المصدر