تفاعل #417951

معادلة التفاعل

4-bromo-5-fluoro-pyridin-2-ol

ethyliodide

→

4-Bromo-2-ethoxy-5-fluoro-pyridine

المذيبات

DCM

ظروف التفاعل

المعالجة

1. 1
   أخرىThe reaction is quenched by the addition of water
2. 2
   workup.ADDITIONDCM is added
3. 3
   ترشيحthe resulting mixture is filtered
4. 4
   تجفيفdried over MgSO4
5. 5
   ترشيحfiltered again
6. 6
   أخرىthe solvent is removed in vacuo

الإجراء التجريبي

0.20 g (1.04 mmol) 4-bromo-5-fluoro-pyridin-2-ol, 0.83 mL (10.4 mmol) ethyliodide and 0.43 g (1.56 mmol) Ag2CO3 are added to 5 mL DCM and stirred at r.t. over night. The reaction is quenched by the addition of water. DCM is added, the resulting mixture is filtered and the organic layer is separted, dried over MgSO4, filtered again and the solvent is removed in vacuo.

المصدر