تفاعل #417948

معادلة التفاعل

2-bromo-5-hydroxypyridine

1-bromopropane

K2CO3

→

2-Bromo-5-propoxy-pyridine

المذيبات

ACN

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةat reflux over night
2. 2
   أخرىAfterwards the reaction is quenched by the addition of water
3. 3
   استخلاصextracted with TBME
4. 4
   تجفيفdried over MgSO4
5. 5
   ترشيحfiltered
6. 6
   أخرىthe solvent is removed in vacuo
7. 7
   أخرىThe crude product is purified by column chromatography (silica gel, PE/EtOAc)

الإجراء التجريبي

10.0 g (57.5 mmol) 2-bromo-5-hydroxypyridine, 28.3 g (230 mmol) 1-bromopropane and 19.9 g (143.7 mmol) K2CO3 are added to 1 L ACN and stirred at reflux over night. Afterwards the reaction is quenched by the addition of water and extracted with TBME. The org. layers are combined, dried over MgSO4, filtered and the solvent is removed in vacuo. The crude product is purified by column chromatography (silica gel, PE/EtOAc).

المصدر