تفاعل #417944

معادلة التفاعل

BOC2O

(S)-1-(4-bromophenyl)ethylamine

Na2CO3

→

(S)-tert-Butyl 1-(4-bromophenyl)ethylcarbamate

المذيبات

THF

DCM

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONThen the mixture is poured onto water
2. 2
   workup.STIRRINGstirred for additional 20 min
3. 3
   أخرىThe layers are separated
4. 4
   غسيلlayer is washed with water (2×)
5. 5
   تجفيفdried over Na2SO4
6. 6
   ترشيحfiltered
7. 7
   أخرىthe solvent is removed in vacuo

الإجراء التجريبي

To 150 g (735 mmol) (S)-1-(4-bromophenyl)ethylamine in 2 L DCM are added 459 mL (918 mmol) of an aq. Na2CO3 solution (c=2 mol/L). To this mixture a solution of 164 g (749 mmol) BOC2O in 350 mL THF is added dropwise at r.t. and stirring is continued for 1 h. Then the mixture is poured onto water and stirred for additional 20 min. The layers are separated, the org. layer is washed with water (2×), dried over Na2SO4, filtered and the solvent is removed in vacuo.

المصدر