تفاعل #417943

معادلة التفاعل

(S)-1-(4-bromophenyl)ethylamine

acetic anhydride

→

(S)—N-(1-(4-Bromophenyl)ethyl)acetamide

المذيبات

DCM

ظروف التفاعل

المعالجة

1. 1
   أخرىThen the cooling is removed
2. 2
   غسيلAfterwards the mixture is consecutively washed with water, sat. aq. NaHCO3 solution, water, diluted aq. citric acid solution and again water
3. 3
   تجفيفlayer is dried over MgSO4
4. 4
   ترشيحfiltered
5. 5
   أخرىthe solvent is removed in vacuo

الإجراء التجريبي

To 200 g (1.00 mol) (S)-1-(4-bromophenyl)ethylamine in 800 mL DCM are slowly added 94.5 mL (1.00 mol) acetic anhydride while cooling the mixture to 20-30° C. Then the cooling is removed and the reaction mixture is stirred at r.t. over night. Afterwards the mixture is consecutively washed with water, sat. aq. NaHCO3 solution, water, diluted aq. citric acid solution and again water. The org. layer is dried over MgSO4, filtered and the solvent is removed in vacuo.

المصدر