تفاعل #417942

معادلة التفاعل

bis(pinacolato)diboron

potassium acetate

bromide

3,4-diamino-benzoic acid ethyl ester

→

2

4-methoxycarbonylphenylboronic acid

المذيبات

dioxane

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   غسيلThe organic phase was washed with H2O (20 mL)
2. 2
   تجفيفdried over sodium sulfate
3. 3
   تركيزconcentrated in vacuo
4. 4
   أخرىThe residue was further purified by silica gel column chromatography (haxanes/ethyl acetate=1/4 to 0/1 (v/v))

الإجراء التجريبي

Referring to Scheme 11-1, to a solution of the bromide 1 (2.0 g, 4.2 mmol, prepared according to published conditions) in dioxane (60 mL) was added bis(pinacolato)diboron (4.32 g, 17 mmol), Pd(PPh3)4 (0.49 g, 0.42 mmol) and potassium acetate (2.06 g, 21 mmol) under nitrogen atmosphere. The reaction mixture was stirred at 80° C. for 5 h, and then diluted with ethyl acetate (150 mL). The organic phase was washed with H2O (20 mL), dried over sodium sulfate and concentrated in vacuo. The residue was further purified by silica gel column chromatography (haxanes/ethyl acetate=1/4 to 0/1 (v/v)) to give 2 (1.73 g, 79% yield). LC-MS (ESI): m/z 523.3 (M+H)+.

المصدر