تفاعل #417928

معادلة التفاعل

3-(2-Trifluoromethyl-phenylmethanesulfonylmethyl)-pyridine-2-carboxylic acid methyl ester

tetrahydrofurane

HCl

→

colourless crystals

المردود 37.3%

6,6-Dioxo-7-(2-trifluoromethyl-phenyl)-5,6-dihydro-thiopyrano[4,3-b]pyridin-8-ol

المردود 37.3%

المذيبات

ethylacetate cyclohexane

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONdiluted with methylenehloride
2. 2
   استخلاصextracted
3. 3
   تجفيفThe organic phase was dried with sodiumsulfate
4. 4
   تركيزconcentrated

الإجراء التجريبي

To a solution of 3-(2-Trifluoromethyl-phenylmethanesulfonylmethyl)-pyridine-2-carboxylic acid methyl ester (7.58 g, 19.6 mmol) in tetrahydrofurane (160 ml) potassium tert-butoxide (2.20 g, 19.57 mmol) was added at room temperature and stirring was continued for 3.5 h. 1M HCl was added, diluted with methylenehloride and extracted. The organic phase was dried with sodiumsulfate and concentrated. Chromatography over silica with ethylacetate/cyclohexane gave 2.50 g colourless crystals (7.32 mmol).

المصدر