تفاعل #417925

معادلة التفاعل

32

methyl 4-hydroxybenzoate

K2CO3

13

1-iodoundec-4Z-ene

→

yellow oil

المردود 100.1%

methyl 4-(undec-4Z-enyloxy)benzoate

المردود 100.1%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىAfter reaction for 7 hours at 90° C.
2. 2
   تركيزthe reaction medium is concentrated
3. 3
   غسيلwashed with water

الإجراء التجريبي

90 mg of 32 (590 μmol) and 81 mg of K2CO3 (590 μmol) are added to 150 mg of 13 (535 μmol) in anhydrous DMF (2 mL). After reaction for 7 hours at 90° C., the reaction medium is concentrated, taken up in DCM and then washed with water. 163 mg of a yellow oil are obtained, and are chromatographed on silica gel in pentane/ethyl acetate (80/1). 129 mg of the expected coupling product are isolated in the form of a yellow oil, i.e. a yield of 79%.

المصدر