تفاعل #41781

معادلة التفاعل

dimethyl sulfate

methyl5-[3-nitro-4-(2,2,2-trifluoroacetylamino)phenoxy]-pyridine-3-carboxylate

acetonitrile

sodium hydroxide

toluene

→

methyl-4-[4-(methylamino)-3-nitrophenoxy]pyridine-3-carboxylate

ظروف التفاعل

المعالجة

1. 1
   أخرىevaporated
2. 2
   غسيلwashed with water, brine
3. 3
   أخرىdried
4. 4
   أخرىevaporated
5. 5
   أخرىThe crude was purified by column chromatography

الإجراء التجريبي

To the solution of the methyl5-[3-nitro-4-(2,2,2-trifluoroacetylamino)phenoxy]-pyridine-3-carboxylate (1 eq) in a mixture of toluene, acetonitrile and sodium hydroxide solution (50%) was added benzyltrimethylammonium chloride (1 eq) and dimethyl sulfate (1.2 eq). The biphasic mixture was stirred overnight at room temperature and evaporated. The mixture was taken up in ethyl acetate, washed with water, brine, dried and evaporated. The crude was purified by column chromatography to afford methyl-4-[4-(methylamino)-3-nitrophenoxy]pyridine-3-carboxylate. MS: MH+=303.

المصدر