تفاعل #41733

معادلة التفاعل

2-chloro-5-methoxybenzoxazole

4-bromoaniline

diisopropylethylamine

→

(4-bromophenyl)(5-methoxybenzoxazol-2-yl)amine

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   تركيزThe resultant mixture was concentrated
2. 2
   أخرىpartitioned between ethyl acetate and water
3. 3
   غسيلThe organic layer was washed with brine
4. 4
   أخرىdried
5. 5
   أخرىPurification on silica gel

الإجراء التجريبي

The mixture containing 2-chloro-5-methoxybenzoxazole (1 eq), 4-bromoaniline (2 eq) and diisopropylethylamine was refluxed in dimethylformamide. The resultant mixture was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with brine and dried. Purification on silica gel gave (4-bromophenyl)(5-methoxybenzoxazol-2-yl)amine. MS: MH+=318

المصدر