تفاعل #41729

معادلة التفاعل

H2SO4

4-[2-(4-chlorophenylamino)-1-methyl-1H-benzoimidazol-5-yloxy]-pyridine-2-carbonitrile

ethylenediamine

→

(4-Chloro-phenyl)-{5-[2-(4,5-dihydro-1H-imidazol-2-yl)pyridin-4-yloxy]-1-methyl-1H-benzoimidazol-2-yl}-amine

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONpoured onto ice/NaHCO3
2. 2
   أخرىThe solid product was collected
3. 3
   غسيلwashed (H2O)
4. 4
   أخرىair-dried 59.8 mg

الإجراء التجريبي

H2SO4 (454 mg) was added cautiously to a suspension of 4-[2-(4-chlorophenylamino)-1-methyl-1H-benzoimidazol-5-yloxy]-pyridine-2-carbonitrile (60.0 mg) in ethylenediamine (0.50 mL). The system was shaken at room temperature for 72 hrs, then poured onto ice/NaHCO3. The solid product was collected, washed (H2O) air-dried 59.8 mg. M/z=419 (M+1).

المصدر