تفاعل #41722

معادلة التفاعل

2-[(4-bromophenyl)amino]benzothiazol-5-ol

Potassiumbis(trimethylsilyl)amide

4-chloro(2-pyridyl)-N-methylcarboxamide

Potassium carbonate

→

desired product

(4-{2-[(4-bromophenyl)amino]benzothiazol-5-yloxy}(2-pyridyl))-N-methylcarboxamide

المذيبات

dimethylformamide

ظروف التفاعل

المعالجة

1. 1
   أخرىmicrowaved for 6 mins at 150° C
2. 2
   تركيزThe reaction mixture was then concentrated
3. 3
   أخرىpartitioned between ethyl acetate and water
4. 4
   أخرىThe organic layer was separated
5. 5
   غسيلwashed with brine
6. 6
   أخرىdried
7. 7
   ترشيحfiltered
8. 8
   تركيزconcentrated
9. 9
   أخرىPurification on Prep LC

الإجراء التجريبي

The mixture containing 2-[(4-bromophenyl)amino]benzothiazol-5-ol (1 eq), Potassiumbis(trimethylsilyl)amide (4 eq), was stirred in dimethylformamide for 30 min at room temperature. To this mixture was added (4-chloro(2-pyridyl)-N-methylcarboxamide (1 eq) and Potassium carbonate (1.2 eq) and microwaved for 6 mins at 150° C. The reaction mixture was then concentrated and partitioned between ethyl acetate and water. The organic layer was separated and washed with brine, dried, filtered and concentrated. Purification on Prep LC yielded the desired product. MS: MH+=455

المصدر