تفاعل #41720

معادلة التفاعل

2-bromo-5-methoxybenzthiazole

4-Bromoaniline

→

desired product

(4-bromophenyl)(5-methoxybenzothiazol-2-yl)amine

المذيبات

NMP

ظروف التفاعل

المعالجة

1. 1
   تركيزThe resultant mixture was concentrated
2. 2
   أخرىpartitioned between ethyl acetate and water
3. 3
   غسيلThe organic layer was washed with brine
4. 4
   أخرىdried
5. 5
   أخرىPurification on silica gel

الإجراء التجريبي

The mixture containing 2-bromo-5-methoxybenzthiazole (1 eq), 4-Bromoaniline (2 eq) and disopropylethylamine was subjected to microwave in NMP at 220° C. The resultant mixture was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with brine and dried. Purification on silica gel gave the desired product. MS: MH+=335

المصدر