تفاعل #41679

معادلة التفاعل

hydrogen

t-butyl 2-(4-amino-2-((2′-fluorobiphenyl-4-yl)oxy)-5-nitrophenyl)pyrrolidine-1-carboxylate

→

t-butyl 2-(4,5-diamino-2-((2′-fluorobiphenyl-4-yl)oxy)phenyl)pyrrolidine 1-carboxylate

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   أخرىthe reaction liquid
2. 2
   أخرىThe catalyst was removed through filtration through Celite
3. 3
   أخرىthe solvent was evaporated away under reduced pressure
4. 4
   أخرىthe residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=1/1)
5. 5
   أخرىto obtain the entitled compound as a brown oily substance

الإجراء التجريبي

1 ml of developed Raney nickel was added to a methanol (5 ml) solution of 410 mg of t-butyl 2-(4-amino-2-((2′-fluorobiphenyl-4-yl)oxy)-5-nitrophenyl)pyrrolidine-1-carboxylate, and the reaction liquid was stirred in a hydrogen atmosphere at room temperature for 1 day. The catalyst was removed through filtration through Celite, and the solvent was evaporated away under reduced pressure, and the residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=1/1) to obtain the entitled compound as a brown oily substance.

المصدر