تفاعل #41678

معادلة التفاعل

2′-fluorobiphenyl-4-ol

potassium carbonate

N,N-dimethylformamide

t-butyl 2-(4-amino-2-fluoro-5-nitrophenyl)pyrrolidine-1-carboxylate

→

compound

t-butyl 2-(4-amino-2-((2′-fluorobiphenyl-4-yl)oxy)-5-nitrophenyl)pyrrolidine-1-carboxylate

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   أخرىthe reaction liquid
2. 2
   أخرىThe reaction liquid
3. 3
   غسيلwashed with water and saturated saline in order
4. 4
   تجفيفdried with anhydrous magnesium sulfate
5. 5
   أخرىThe solvent was evaporated away
6. 6
   أخرىthe resulting residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=5/1)

الإجراء التجريبي

200 mg of 2′-fluorobiphenyl-4-ol and 184 mg of potassium carbonate were added to an N,N-dimethylformamide (3 ml) solution of 288 mg of t-butyl 2-(4-amino-2-fluoro-5-nitrophenyl)pyrrolidine-1-carboxylate, and the reaction liquid was stirred overnight at 80° C. The reaction liquid was diluted with ethyl acetate, washed with water and saturated saline in order, and dried with anhydrous magnesium sulfate. The solvent was evaporated away, and the resulting residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=5/1) to obtain the entitled compound as a yellow solid.

المصدر