تفاعل #416776

معادلة التفاعل

potassium carbonate

N-methylhydroxylamine hydrochloride

potassium carbonate

2, 3-dibromobutyryl chloride

→

4-bromo-2,5-dimethyl-3-isoxazolidinone

المردود 57.3%

المذيبات

methylene chloride

ظروف التفاعل

المعالجة

1. 1
   ترشيحAfter three days the mixture was filtered
2. 2
   تركيزthe filtrate was concentrated
3. 3
   أخرىthe concentrate was chromatographed on silica gel with 40% ethyl acetate-hexane

الإجراء التجريبي

To a stirred mixture of 12.5 g (150 mmol) of N-methylhydroxylamine hydrochloride, 20.7 g (150 mmol) of potassium carbonate and 4.1 g (15 mmol) of tetrabutylammonium hydrogen sulfate in 250 ml of methylene chloride, there was added 2, 3-dibromobutyryl chloride (42 g,150 mmol) followed by the addition of 41.4 g (300 mmol) of potassium carbonate. After three days the mixture was filtered, the filtrate was concentrated and the concentrate was chromatographed on silica gel with 40% ethyl acetate-hexane to afford 16.8 g (86 mmol, 57%) of 4-bromo-2,5-dimethyl-3-isoxazolidinone.

المصدر