تفاعل #41660

معادلة التفاعل

t-butyldimethylsilyl chloride

imidazole

dimethylformamide

3-hydroxydihydrofuran-2-(3H)-one

→

3-((t-butyl(dimethyl)silyl)oxy)dihydrofuran-2 (3H)-one

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   أخرىthe reaction liquid
2. 2
   أخرىThe reaction liquid
3. 3
   غسيلwashed with water
4. 4
   تجفيفdried with anhydrous sodium sulfate
5. 5
   أخرىThe solvent was evaporated away under reduced pressure
6. 6
   أخرىthe resulting residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=5/1)
7. 7
   أخرىto obtain the entitled compound as a colorless oily substance

الإجراء التجريبي

9.0 g of imidazole and 15.9 g of t-butyldimethylsilyl chloride were added in order to a dimethylformamide (180 ml) solution of 9.0 g of 3-hydroxydihydrofuran-2-(3H)-one, and the reaction liquid was stirred for 1 hour at room temperature. The reaction liquid was diluted with ethyl acetate, washed with water, and dried with anhydrous sodium sulfate. The solvent was evaporated away under reduced pressure, and the resulting residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=5/1) to obtain the entitled compound as a colorless oily substance.

المصدر