تفاعل #41632

معادلة التفاعل

water

t-butyl 2-(4-amino-2-fluoro-phenyl)-pyrrole-1-carboxylate

hydrogen

→

t-butyl 2-(4-amino-2-fluoro-phenyl)-pyrrolidine-1-carboxylate

المذيبات

2-propanol

ظروف التفاعل

المعالجة

1. 1
   أخرىThe catalyst was removed through filtration through Celite
2. 2
   أخرىthe solvent was evaporated away under reduced pressure
3. 3
   أخرىthe residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=1/1)
4. 4
   أخرىto obtain the entitled compound as a brown oily substance

الإجراء التجريبي

5 ml of water and 660 mg of 5% platinum-carbon catalyst were added to a 2-propanol (50 ml) solution of 2.2 g of t-butyl 2-(4-amino-2-fluoro-phenyl)-pyrrole-1-carboxylate, and stirred in a hydrogen atmosphere under a pressure of 50 kgf/cm2 at 50° C. for 1 day. The catalyst was removed through filtration through Celite, the solvent was evaporated away under reduced pressure, and the residue was purified through silica gel column chromatography (developing solvent: hexane/ethyl acetate=1/1) to obtain the entitled compound as a brown oily substance.

المصدر