تفاعل #416041

معادلة التفاعل

benzyl chloride

(±)-6-hydroxy-2-methoxy-2,5,7,8-tetramethylchroman

potassium carbonate

dimethylsulfoxide

→

(±)-6-benzyloxy-2-methoxy-2,5,7,8-tetramethylchroman

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONA mixture of 70.8 g
2. 2
   استخلاصextracted with ether
3. 3
   غسيلThe ether solutions were washed with brine
4. 4
   تجفيفdried over sodium sulfate

الإجراء التجريبي

A mixture of 70.8 g. of (±)-6-hydroxy-2-methoxy-2,5,7,8-tetramethylchroman, 90.9 g. of anhydrous potassium carbonate, 300 ml. of dimethylsulfoxide and 69 ml. of benzyl chloride was stirred at 23° under N2 for 24 hours. The suspension was poured into water and extracted with ether. The ether solutions were washed with brine, dried over sodium sulfate and stripped of solvent to give (±)-6-benzyloxy-2-methoxy-2,5,7,8-tetramethylchroman as an oil which solidified to a light yellow mass, m.p. 70°-72.5°.

المصدر