تفاعل #415773

معادلة التفاعل

N-CBZ-L-glutamic acid-α-ethyl ester

N-hydroxysuccinimide

dicyclohexylcarbodimide

→

N-CBZ-O5 -Succinimido-L-Glutamic Acid O-Ethyl Ester

المذيبات

dioxane

ظروف التفاعل

المعالجة

1. 1
   ترشيحthe mixture was filtered
2. 2
   أخرىto remove dicyclohexylurea
3. 3
   تركيزThe filtrate was concentrated in vacuo
4. 4
   أخرىto give an oil
5. 5
   أخرىto crystallize
6. 6
   أخرىwas used in the next step without further purification

الإجراء التجريبي

To a solution of N-CBZ-L-glutamic acid-α-ethyl ester (0.096 mole, 29.6 g.) and N-hydroxysuccinimide (0.1 mole, 11.5 g.) in 200 ml. of dioxane was added with stirring at room temperature (0.1 mole, 21 g.) of dicyclohexylcarbodimide. After stirring 24 hours at room temperature, the mixture was filtered to remove dicyclohexylurea. The filtrate was concentrated in vacuo to give an oil. This oil failed to crystallize and was used in the next step without further purification.

المصدر