تفاعل #41570

معادلة التفاعل

2-hydroxy-benzonitrile

potassium carbonate

N-methylpyrrolidinone

5-fluoro-4-(6-methanesulfonyl-pyridin-3-yloxy)-2-nitro-phenylamine

→

5-(2-cyano-phenoxy)-4-(6-methanesulfonyl-pyridin-3-yloxy)-2-nitro-phenylamine

المذيبات

Water

ظروف التفاعل

المعالجة

1. 1
   أخرىobtained in (step 3)
2. 2
   أخرىthe reaction liquid
3. 3
   ترشيحthe deposit was taken out through filtration
4. 4
   أخرىto obtain the entitled compound

الإجراء التجريبي

60 mg of 2-hydroxy-benzonitrile and 70 mg of potassium carbonate were added to an N-methylpyrrolidinone (2 ml) solution of 150 mg of 5-fluoro-4-(6-methanesulfonyl-pyridin-3-yloxy)-2-nitro-phenylamine obtained in (step 3), and the reaction liquid was stirred at 90° C. for 5 hours. Water was added to the reaction liquid, and the deposit was taken out through filtration to obtain the entitled compound.

المصدر