تفاعل #415442

معادلة التفاعل

4-p-chlorophenylpiperidin-4-ol

formaldehyde

6,7-dimethoxy-1-tetralone

dimethylamine

CH3I

Na2CO3

→

4-p-chlorophenyl-4-hydroxypiperidinomethyl-6,7-dimethoxy-1-tetralone

المذيبات

DMF

ظروف التفاعل

الإجراء التجريبي

2 g. of 4-p-chlorophenylpiperidin-4-ol are dissolved in 30 ml. of DMF. 4.05 g. of 2-dimethylaminomethyl-6,7-dimethoxy-1-tetralone methiodide, obtainable by reacting 6,7-dimethoxy-1-tetralone with dimethylamine and formaldehyde and quaternizing the product with CH3I, and 1 g. of Na2CO3 are added and the mixture is stirred for 4 hours at 20° under N2. After the customary work up, 2-(4-p-chlorophenyl-4-hydroxypiperidinomethyl-6,7-dimethoxy-1-tetralone is obtained. Hydrochloride, m.p. 227°-228°.

المصدر