تفاعل #41537

معادلة التفاعل

chloromethyl methyl ether

sodium hydride

tetrahydrofuran

ethyl 3-bromo-4-hydroxybenzoate

→

compound

ethyl 3-bromo-4-methoxymethoxybenzoate

المذيبات

ethyl acetate

ظروف التفاعل

المعالجة

1. 1
   أخرىproduced
2. 2
   درجة الحرارة437, with cooling with ice
3. 3
   أخرىthe reaction liquid
4. 4
   أخرىthe reaction liquid
5. 5
   workup.STIRRINGwas stirred overnight at room temperature
6. 6
   أخرىThe reaction liquid
7. 7
   غسيلwashed with water
8. 8
   استخلاصthe aqueous layer was extracted with ethyl acetate
9. 9
   تجفيفdried with anhydrous magnesium sulfate
10. 10
    أخرىThe solvent was evaporated away under reduced pressure
11. 11
    ترشيحtaken out through filtration

الإجراء التجريبي

5.5 g of sodium hydride was added to a tetrahydrofuran (300 ml) solution of 20.5 g of ethyl 3-bromo-4-hydroxybenzoate produced according to the method described in Monatsh. Chem.; 22; 1901; 437, with cooling with ice, and the reaction liquid was stirred for 30 minutes, and then, at the same temperature, 10 ml of chloromethyl methyl ether was added to the reaction liquid, and the reaction liquid was stirred overnight at room temperature. The reaction liquid was diluted with ethyl acetate, and washed with water, and the aqueous layer was extracted with ethyl acetate, and dried with anhydrous magnesium sulfate. The solvent was evaporated away under reduced pressure, and the resulting solid was suspended in hexane and then taken out through filtration to obtain the entitled compound as a white solid.

المصدر