تفاعل #415360

معادلة التفاعل

oxetane

N,N,N-trimethyl-[3-(methylamino)]-1-propanaminium bromide

→

3-[N'-(3-Hydroxypropyl)-N'-methylamino]-N,N,N-trimethyl-1-propanaminium Bromide

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONA mixture of 20 g
2. 2
   أخرىThe solution is evaporated in vacuo
3. 3
   workup.DISSOLUTIONthe residue is dissolved in 50 ml
4. 4
   ترشيحof acetonitrile and filtered
5. 5
   أخرىUpon evaporation the desired product
6. 6
   أخرىcrystallizes
7. 7
   أخرىThe product may be recrystallized from acetonitrile

الإجراء التجريبي

A mixture of 20 g. of oxetane (0.34 mole), 32.8 g. of N,N,N-trimethyl-[3-(methylamino)]-1-propanaminium bromide (0.156 mole) and 22 ml. water is heated in a sealed tube at 100° for 15 hours. The solution is evaporated in vacuo and the residue is dissolved in 50 ml. of acetonitrile and filtered. Upon evaporation the desired product crystallizes. The product may be recrystallized from acetonitrile.

المصدر