تفاعل #415082

معادلة التفاعل

(E,E)-farnesol

PBr3

→

farnesyl bromide

المذيبات

diethyl ether

diethyl ether

ظروف التفاعل

المعالجة

1. 1
   أخرىquenched with H2O
2. 2
   أخرىseparated
3. 3
   غسيلThe organic phase was washed with 15 ml of NaHCO3, 15 ml of H2O, and 15 ml of brine
4. 4
   تجفيفdried over MgSO4
5. 5
   أخرىevaporated

الإجراء التجريبي

A solution of 2.00 g (9.0 mmol) of (E,E)-farnesol in 20 ml of dry diethyl ether at 0° C. under argon in the dark was treated dropwise with a solution of 735 μl (4.0 mmol, 0.45 eq.) of PBr3 in 4 ml of dry diethyl ether. The resultant mixture was stirred at 0° C. for one hour, then quenched with H2O and separated. The organic phase was washed with 15 ml of NaHCO3, 15 ml of H2O, and 15 ml of brine, dried over MgSO4 and evaporated to provide 2.47 g of crude farnesyl bromide as a clear oil.

المصدر