تفاعل #41460

معادلة التفاعل

HCl

3-hydrazinylbenzoic acid

2-fluoro-5-iodobenzaldehyde

caesium carbonate

→

title compound

المردود 98.0%

3-(2-(2-fluoro-5-iodobenzylidene)hydrazinyl)benzoic acid

المردود 98.0%

المذيبات

Water

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىThe beige-orange precipitate that formed
2. 2
   أخرىwas collected by,
3. 3
   ترشيحfiltration
4. 4
   غسيلwashed with water
5. 5
   أخرىdried in vacuo

الإجراء التجريبي

3-hydrazinylbenzoic acid (1.52 g, 10 mmol)), 2-fluoro-5-iodobenzaldehyde (2.5 g, 10 mmol) and caesium carbonate (3.26 g, 10 mmol) were stirred in DMF (10 mL) at r.t. under argon atmosphere for 2.5 h. Water (40 mL) was added and the clear solution was acidified with aqueous HCl (1.7 M). The beige-orange precipitate that formed was collected by, filtration, washed with water and dried in vacuo to give the title compound (3.75 g, 98%).

المصدر