تفاعل #41456

معادلة التفاعل

HCl

4-hydrazinylbenzoic acid

2-fluoro-5-iodobenzaldehyde

caesium carbonate

→

4-(2-(2-fluoro-5-iodobenzylidene)hydrazinyl)benzoic acid

المردود 98.1%

المذيبات

Water

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىThe light yellow precipitate that formed
2. 2
   ترشيحwas collected by filtration
3. 3
   غسيلwashed with water
4. 4
   أخرىdried in vacuo

الإجراء التجريبي

4-hydrazinylbenzoic acid (1.54 g, 10 mmol), 2-fluoro-5-iodobenzaldehyde (2.52 g, 10 mmol) and caesium carbonate (3.27 g, 10 mmol) was stirred in DMF (10 mL) at r.t. for 70 min. Water (40 mL) was then added and the clear solution was acidified with aqueous HCl (1.7 M). The light yellow precipitate that formed was collected by filtration, washed with water and dried in vacuo to give 4-(2-(2-fluoro-5-iodobenzylidene)hydrazinyl)benzoic acid (3.77 g, 98%)

المصدر