تفاعل #41455

معادلة التفاعل

4-(2-(2-fluoro-5-iodobenzylidene)hydrazinyl)benzoic acid

potassium tert-butoxide

HCl

→

4-(5-iodo-1H-indazol-1-yl)benzoic acid

المردود 94.1%

المذيبات

NMP

water

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةThe mixture was then cooled
2. 2
   أخرىThe precipitate that formed
3. 3
   ترشيحwas collected by filtration
4. 4
   أخرىdried in vacuo

الإجراء التجريبي

4-(2-(2-fluoro-5-iodobenzylidene)hydrazinyl)benzoic acid (141d, 3.42 g, 8.9 mmol) and potassium tert-butoxide (2.29 g, 20.5 mmol) was stirred under argon atmosphere in NMP (45 mL) at 150° C. for 15 min. The mixture was then cooled, diluted with water and acidified with aqueous HCl (1.7 M). The precipitate that formed was collected by filtration and dried in vacuo to give crude 4-(5-iodo-1H-indazol-1-yl)benzoic acid (3.05 g, 94%)

المصدر