تفاعل #41437

معادلة التفاعل

5-iodo-1H-indazole

isopropyl bromide

KOtBu

ethyl acetate

→

subtitle compound

المردود 52.0%

5-Iodo-1-isopropyl-1H-indazole

المردود 52.0%

5-iodo-2-isopropyl-2H-indazole

المردود 40.0%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with water (2×50 ml)
2. 2
   تجفيفdried with Na2SO4
3. 3
   أخرىEvaporation of solvent and purification by flash chromatography on silica gel (n-heptane/ethyl acetate)

الإجراء التجريبي

A mixture of 5-iodo-1H-indazole (488 mg, 2 mmol), isopropyl bromide (244 mg, 2 mmol), and KOtBu (336 mg, 3 mmol) in dry DMF (4 ml) was stirred at r.t. overnight. Then it was dilited with ethyl acetate (50 ml), washed with water (2×50 ml), and dried with Na2SO4. Evaporation of solvent and purification by flash chromatography on silica gel (n-heptane/ethyl acetate) afforded the subtitle compound (298 mg, 52%) along with 5-iodo-2-isopropyl-2H-indazole (227 mg, 40%).

المصدر