تفاعل #414295

معادلة التفاعل

Isopropyl N-cyano-3-pyridinecarboximidate

2-(4-aminophenyl)ethylamine

→

N-cyano-N'-[2-(4-aminophenyl)ethyl]-3-pyridinecarboximidamide

المردود 63.0%

المذيبات

methanol

ظروف التفاعل

المعالجة

1. 1
   تركيزthe reaction solution was concentrated under reduced pressure
2. 2
   تركيزThe residual concentrate
3. 3
   أخرىwas crystallized from methanol-diethyl ether

الإجراء التجريبي

Isopropyl N-cyano-3-pyridinecarboximidate (1.0 g, 5.3 mmol) was dissolved in methanol (15 ml), and 2-(4-aminophenyl)ethylamine (0.80 g; 5.8 mmol) was added. The mixture was stirred at room temperature for 1 hour. After the reaction was completed, the reaction solution was concentrated under reduced pressure. The residual concentrate was crystallized from methanol-diethyl ether to give N-cyano-N'-[2-(4-aminophenyl)ethyl]-3-pyridinecarboximidamide (0.88 g, 3.3 mmol, yield: 63%) as colorless needles.

المصدر