تفاعل #413848

معادلة التفاعل

2,6-dimethylphenol

N-(2-chloroethyl)pyrrolidine hydrochloride

potassium carbonate

→

N-[2-(2,6-dimethylphenoxy)ethyl]pyrrolidine hydrochloride

المردود 64.8%

المذيبات

ethyl methyl ketone

ظروف التفاعل

المعالجة

1. 1
   تركيزThe reaction mixture was concentrated under reduced pressure
2. 2
   أخرىthe residue was partitioned between water and ether
3. 3
   أخرىthe organic phase was separated off
4. 4
   غسيلwashed with water
5. 5
   أخرىdried
6. 6
   workup.ADDITIONexcess ethereal hydrogen chloride solution was added
7. 7
   أخرىThe precipitated product was recrystallized from 10/1 ethyl acetate/isopropanol

الإجراء التجريبي

46.7 g (0.38 mole) of 2,6-dimethylphenol, 65.0 g (0.38 mole) of N-(2-chloroethyl)pyrrolidine hydrochloride, 210.1 g (1.52 mole) of potassium carbonate and 2 g of NaI in 300 ml of ethyl methyl ketone were refluxed for 48 h. The reaction mixture was concentrated under reduced pressure, the residue was partitioned between water and ether, the organic phase was separated off, washed with water and dried, and excess ethereal hydrogen chloride solution was added. The precipitated product was recrystallized from 10/1 ethyl acetate/isopropanol. 63 g of N-[2-(2,6-dimethylphenoxy)ethyl]pyrrolidine hydrochloride were obtained.

المصدر