تفاعل #41344

معادلة التفاعل

5-Iodo-6-methylindazole

p-fluorobenzeneboronic acid

pyridine

p-fluorobenzeneboronic acid

pyridine

→

subtitle compound

المردود 51.1%

1-(4-Fluorophenyl)-5-iodo-6-methylindazole

المردود 51.1%

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   ترشيحThe mixture was filtered through celite
2. 2
   تركيزThe filtrate was concentrated
3. 3
   أخرىpurified by column chromatography (SiO2, toluene)

الإجراء التجريبي

5-Iodo-6-methylindazole (1.3 g, 5.0 mmol), p-fluorobenzeneboronic acid (1.4 g, 10 mmol), anhydrous copper(II) acetate (1.4 g, 7.5 mmol) and pyridine (0.80 mL, 10 mmol) were stirred in dichloromethane (30 mL) overnight. Additional portions of p-fluorobenzeneboronic acid (0.47 g, 3.4 mmol), anhydrous copper(II) acetate (0.45 g, 2.5 mmol) and pyridine (0.27 mL, 3.4 mmol) were added. The mixture was filtered through celite after stirring for an additional night. The filtrate was concentrated and purified by column chromatography (SiO2, toluene) to give the subtitle compound (0.90 g, 51%) as a light orange powder.

المصدر