تفاعل #41302

معادلة التفاعل

(S)-tert-butyl 1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate

2-Naphthylmagnesiumbromide

THF

→

subtitle compound

tert-butyl[(1S)-1-methyl-2-(2-naphthyl)-2-oxoethyl]carbamate

ظروف التفاعل

المعالجة

1. 1
   أخرىThe obtained material was crystallised from Heptane

الإجراء التجريبي

The subtitle compound was prepared analogous to the method described in Example 19 (step 19d), starting from (S)-tert-butyl 1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate (1.86 g, 8 mmol) and a freshly prepared 2-Naphthylmagnesiumbromide 1M solution in THF (8 mL, 8 mmol). The obtained material was crystallised from Heptane. Yield 350 mg (14%).

المصدر