تفاعل #41267

معادلة التفاعل

hydroxylamine hydrochloride

HATU

DIPEA

E-3-chloro-4-hydroxyphenylcinnamic acid

→

title compound

المردود 9.7%

E-3-[3′-chloro-4′-hydroxybiphenyl-4-yl]-N-hydroxy-acrylamide

المردود 9.7%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   أخرىthe solution thus obtained
2. 2
   workup.STIRRINGthe mixture was stirred at room temperature for 2 days
3. 3
   أخرىDMF was removed under reduced pressure
4. 4
   غسيلthe residue was washed with water
5. 5
   أخرىto obtain
6. 6
   ترشيحafter filtration, 140 mg of a crude product
7. 7
   أخرىPurification by flash chromatography on reverse phase ((LiChroprep RP-18, MERCK)
8. 8
   أخرىwater/methanol 1:1 and crystallization from diethyl ether

الإجراء التجريبي

205 mg (0.75 mmol) of E-3-chloro-4-hydroxyphenylcinnamic acid were dissolved under nitrogen in 7.5 ml of DMF, then 285 mg (0.75 mmol) of HATU and 97 μL (0.56 mmol) of DIPEA were added and the solution thus obtained was kept under stirring at room temperature for 2 min. After addition of hydroxylamine hydrochloride (261 mg, 3.75 mmol), the mixture was stirred at room temperature for 2 days. DMF was removed under reduced pressure and the residue was washed with water to obtain, after filtration, 140 mg of a crude product. Purification by flash chromatography on reverse phase ((LiChroprep RP-18, MERCK) using as eluent water/methanol 1:1 and crystallization from diethyl ether afforded 21 mg of the title compound as a white solid. M.p. 172-175° C. Rf=0.16 (RP18 MERCK, H2O/MeOH 1:1).

المصدر