تفاعل #41233

معادلة التفاعل

4,4′-dibromobiphenyl

cesium carbonate

product

Ethyl(3aR,6aR)-hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate

→

title compound

Ethyl(3aR,6aR)-1-(4′-bromo-1,1′-biphenyl-4-yl)hexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxylate

المذيبات

dichloromethane

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONThe catalyst solution was added to the vessel
2. 2
   ترشيحfiltered
3. 3
   أخرىto remove the catalyst
4. 4
   تركيزThe resulting solution was concentrated under reduced pressure
5. 5
   أخرىthe residue was purified by column chromatography

الإجراء التجريبي

The catalyst solution was added to the vessel containing the 4,4′-dibromobiphenyl, cesium carbonate, and the product of Example 41C and the mixture was heated to 98° C. for 12 hours. The mixture was cooled to 20° C. and 80 g of dichloromethane was added. The resulting mixture was stirred and then filtered to remove the catalyst. The resulting solution was concentrated under reduced pressure and the residue was purified by column chromatography to yield 5.65 g of the title compound.

المصدر