تفاعل #41207

معادلة التفاعل

4-piperazin-1-yl-phenol

methyl 3-bromo-butyrate

triethylamine

→

title compound

المردود 59.3%

3-[4-(4-Hydroxy-phenyl)-piperazin-1-yl]-butyric acid methyl ester

المردود 59.3%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONThe mixture was poured onto water
2. 2
   استخلاصextracted with ethyl acetate (50 ml×3)
3. 3
   غسيلThe combined organic layers were washed with brine
4. 4
   تجفيفdried over anhydrous Na2SO4
5. 5
   أخرىevaporated under vacuum to dryness
6. 6
   أخرىThe residue was purified by silica gel flash chromatography (1% methanol in CH2Cl2)

الإجراء التجريبي

To a mixture of 4-piperazin-1-yl-phenol (2 g, 11.2 mmol) and methyl 3-bromo-butyrate (2.03 g, 11.2 mmol) in DMF (5 mL) was added triethylamine (4.5 mL, 11.53 mmol) dropwise and the reaction mixture was stirred at ambient temperature overnight. The mixture was poured onto water and extracted with ethyl acetate (50 ml×3). The combined organic layers were washed with brine, dried over anhydrous Na2SO4 and evaporated under vacuum to dryness. The residue was purified by silica gel flash chromatography (1% methanol in CH2Cl2) to furnish the title compound (1.85 g, 59.3%); MS; m/z 279 (M+H).

المصدر