تفاعل #41156

معادلة التفاعل

Cyclohexylhydrazine hydrochloride

ethyl (ethoxymethylene)-cyanoacetate

sodium acetate

→

5-amino-1-cyclohexyl-1H-pyrazole-4-carboxylic acid ethyl ester

المردود 92.9%

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةthen cooled to room temperature
2. 2
   تركيزconcentrated
3. 3
   أخرىThe residue was partitioned between methylene chloride and water
4. 4
   استخلاصThe separated aqueous phase was extracted with a second portion of methylene chloride
5. 5
   غسيلThe organic phases were successively washed with water and brine
6. 6
   تجفيفdried over sodium sulfate
7. 7
   تركيزconcentrated in vacuo
8. 8
   أخرىThe residue was purified by flash chromatography
9. 9
   غسيلeluting with a gradient of 25-70% ethyl acetate/hexanes

الإجراء التجريبي

Cyclohexylhydrazine hydrochloride (3.057 g, 20.29 mmol, CAS #24214-73-1, purchased from Aldrich) was combined with ethyl (ethoxymethylene)-cyanoacetate (3.390 g, 20.04 mmol) and anhydrous sodium acetate (2.080 g, 25.36 mmol) in 30 mL ethanol. The mixture was heated at 70° C. for 16 hours then cooled to room temperature and concentrated. The residue was partitioned between methylene chloride and water. The separated aqueous phase was extracted with a second portion of methylene chloride. The organic phases were successively washed with water and brine and then combined, dried over sodium sulfate and concentrated in vacuo. The residue was purified by flash chromatography eluting with a gradient of 25-70% ethyl acetate/hexanes to give 5-amino-1-cyclohexyl-1H-pyrazole-4-carboxylic acid ethyl ester (4.42 g, 92%). Mass spectrum: m/z: 238.1 (M+H).

المصدر