تفاعل #41124

معادلة التفاعل

5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide

2-methoxyethylamine

→

5-(2-Methoxy-ethylamino)-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةHeating
2. 2
   أخرىunder microwave irradiation
3. 3
   أخرىprovided
4. 4
   أخرىafter purification by reverse phase HPLC, 5-(2-methoxy-ethylamino)-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (65 mg, 65%) as an off-white powder

الإجراء التجريبي

Heating a mixture of 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (Example 5, 88 mg; 0.30 mmol) and 2-methoxyethylamine (0.26 mL; 3.0 mmol) under microwave irradiation according to the procedure described for Example 14 provided after purification by reverse phase HPLC, 5-(2-methoxy-ethylamino)-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (65 mg, 65%) as an off-white powder. ES-HRMS m/e calcd for C18H29N4O2 (M+H+) 333.2285, found 333.2282.

المصدر