تفاعل #409699

معادلة التفاعل

11-9

[5(R)-methyl-2-oxo-3(S)-(3-oxo-butyl)-pyrrolidin-1-yl]-acetic acid ethyl ester

2-amino-3-formylpyridine

proline

→

11-10

[5(R)-methyl-3(S)-(2-[1,8]naphthyridin-2-yl-ethyl)-2-oxo-pyrrolidin-1-yl]-acetic acid ethyl ester

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةwas heated
2. 2
   درجة الحرارةat reflux for 12 h
3. 3
   أخرىremoval of the solvent
4. 4
   أخرىthe residue was chromatographed (silica gel, 70:25:5 chloroform/ethyl acetate/MeOH)

الإجراء التجريبي

A mixture of 11-9 (220 mg, 0.8619 mmol), 1-4, 2-amino-3-formylpyridine (137 mg, 1.12 mmol) and proline (99 mg, 0.8619 mmol) in absolute ethanol (5 mL) was heated at reflux for 12 h. Following evaporative removal of the solvent, the residue was chromatographed (silica gel, 70:25:5 chloroform/ethyl acetate/MeOH) to give 11-10 as a yellow oil.

المصدر