تفاعل #40954

معادلة التفاعل

water

3-Benzoyl-5-iodo-1H-pyrimidine-2,4-dione

K2CO3

1-bromo-4-chloro-butane

→

title compound

المردود 98.0%

3-Benzoyl-1-(4-chloro-butyl)-5-iodo-1H-pyrimidine-2,4-dione

المردود 98.0%

المذيبات

DMF

ظروف التفاعل

المعالجة

1. 1
   workup.ADDITIONwas added
2. 2
   استخلاصthe mixture was extracted with ethyl acetate
3. 3
   تجفيفThe organic phase was dried (Na2SO4)
4. 4
   ترشيحfiltered
5. 5
   أخرىevaporated
6. 6
   أخرىthe crude was purified by flash chromatography with petroleum ether-ethyl acetate (7-3)

الإجراء التجريبي

3-Benzoyl-5-iodo-1H-pyrimidine-2,4-dione (Prep36, 2.5 g, 7.3 mmol), K2CO3 (1 g, 7.3 mmol) and 1-bromo-4-chloro-butane (2.10 mL, 18 mmol) were suspended in dry DMF (10 mL). After stirring the reaction at room temperature overnight, water was added and the mixture was extracted with ethyl acetate. The organic phase was dried (Na2SO4), filtered and evaporated; the crude was purified by flash chromatography with petroleum ether-ethyl acetate (7-3) to give the title compound as a white solid (3 g, 98% yield).

المصدر