تفاعل #40942

معادلة التفاعل

1-(3-Hydroxy-propyl)-5-(3-methyl-thiophen-2-yl)-1H-pyrimidine-2,4-dione

Dess-Martin periodinane

Ethyl acetate

→

title compound

المردود 50.0%

3-[5-(3-Methyl-thiophen-2-yl)-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl]-propionaldehyde

المردود 50.0%

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   غسيلthe solution was washed with aqueous saturated NaHCO3 solution
2. 2
   تجفيفThe organic phase was dried (Na2SO4)
3. 3
   أخرىevaporated
4. 4
   أخرىThe crude was purified by flash chromatography with ethyl acetate-petroleum ether (7-3)

الإجراء التجريبي

1-(3-Hydroxy-propyl)-5-(3-methyl-thiophen-2-yl)-1H-pyrimidine-2,4-dione (Prep 28.36 mg, 0.13 mmol) was dissolved in dry THF (5 mL), the solution was cooled to 0° C. and then Dess-Martin periodinane (97 mg, 0.22 mmol) was added under nitrogen. The mixture was stirred at room temperature for 1.5 hours. Ethyl acetate was added and the solution was washed with aqueous saturated NaHCO3 solution. The organic phase was dried (Na2SO4) and evaporated. The crude was purified by flash chromatography with ethyl acetate-petroleum ether (7-3) to give 17 mg of the title compound (50% yield).

المصدر