تفاعل #409264

معادلة التفاعل

4-6

[Tert-butoxycarbonyl-(4-oxo-pentyl)-amino]-propionic acid ethyl ester

2-amino-3-formylpyridine

proline

→

4-7

[Tert-butoxycarbonyl-(3-[1,8]naphthyridin-2-yl-propyl)-amino]-propionic acid ethyl ester

المذيبات

ethanol

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةat reflux for 15 h
2. 2
   درجة الحرارةAfter cooling
3. 3
   أخرىevaporation
4. 4
   أخرىthe residue was chromatographed (silica gel, 1:1 chloroform/ethyl acetate)

الإجراء التجريبي

To a solution of 4-6 (12 g, 40 mmol), 2-amino-3-formylpyridine (6.3 g, 52 mmol), proline (4.6 g, 40 mmol) and ethanol (300 mL) was heated at reflux for 15 h. After cooling and evaporation, the residue was chromatographed (silica gel, 1:1 chloroform/ethyl acetate) to give 4-7 as a yellow oil.

المصدر