تفاعل #40808

ord-3748fd020f36428fb4e075cc855cf526

معادلة التفاعل

CCOC(=O)c1ccc(-c2ccccc2)c(-c2ccc(C(F)(F)F)cc2)n1
ethyl 5-phenyl-6-(4-trifluoromethylphenyl)-pyridine-2-carboxylate
CCOC(=O)c1ccc(-c2ccccc2)c(-c2ccc(C(F)(F)F)cc2)n1
Compound 29
CCOC(=O)c1ccc(-c2ccccc2)c(-c2ccc(C(F)(F)F)cc2)n1
ethyl 5-phenyl-6-(4-trifluoromethylphenyl)-pyridine-2-carboxylate
→
COC(=O)c1ccc(-c2ccccc2)c(-c2ccc(C(F)(F)F)cc2)n1
title compound
COC(=O)c1ccc(-c2ccccc2)c(-c2ccc(C(F)(F)F)cc2)n1
Methyl 5-Phenyl-6-(4-trifluoromethylphenyl)-pyridine-2-carboxylate

المتفاعلات

CCOC(=O)c1ccc(-c2ccccc2)c(-c2ccc(C(F)(F)F)cc2)n1
ethyl 5-phenyl-6-(4-trifluoromethylphenyl)-pyridine-2-carboxylate
CCOC(=O)c1ccc(-c2ccccc2)c(-c2ccc(C(F)(F)F)cc2)n1
Compound 29
CCOC(=O)c1ccc(-c2ccccc2)c(-c2ccc(C(F)(F)F)cc2)n1
ethyl 5-phenyl-6-(4-trifluoromethylphenyl)-pyridine-2-carboxylate

الكواشف

O=S(=O)(O)O
H2SO4

المذيبات

CO
MeOH

ظروف التفاعل

الظروف التفصيلية
See reaction.notes.procedure_details.

المعالجة

  1. 1
    أخرىwere reacted

الإجراء التجريبي

Following General Procedure E, ethyl 5-phenyl-6-(4-trifluoromethylphenyl)-pyridine-2-carboxylate (Compound 29, 103 mg, 0.28 mmol) and conc. H2SO4 (5 drops) in MeOH (5 ml) were reacted to produce the title compound as a white solid.

المصدر

DOI: 10.6084/m9.figshare.5104873.v1براءة الاختراع: US07728014B2uspto-grants-2010_06