تفاعل #40751

معادلة التفاعل

acetic acid

NaBH(OAc)3

(1-ethyl-2-naphthalen-1-yl-1H-imidazol-4-yl)-piperidin-4-yl-methanol

cyclobutanone

→

title compound

(1-cyclobutyl-piperidin-4-yl)-(1-ethyl-2-naphthalen-1-yl-1H-imidazol-4-yl)-methanol

المذيبات

CH2Cl2

—

CH2ClCH2Cl

ظروف التفاعل

المعالجة

1. 1
   غسيلwashed with Na2CO3 (1M), H2O and brine
2. 2
   أخرىdried
3. 3
   أخرىsolvent removed
4. 4
   أخرىThe crude is purified by column (2% Et3N, 3% MeOH in EtOAc)

الإجراء التجريبي

To a solution of (1-ethyl-2-naphthalen-1-yl-1H-imidazol-4-yl)-piperidin-4-yl-methanol (0.53 g) in CH2ClCH2Cl (12 ml) is added cyclobutanone (0.95 ml), followed by NaBH(OAc)3 and acetic acid (0.1 ml). The resulting mixture is stirred at rt overnight, diluted with CH2Cl2, washed with Na2CO3 (1M), H2O and brine, dried and solvent removed. The crude is purified by column (2% Et3N, 3% MeOH in EtOAc) to afford the title compound as a white solid, LCMS 390.1 (M+1).

المصدر