تفاعل #40747

معادلة التفاعل

5-methyl-2-naphthalen-1-yl-3H-imidazole-4-carboxylic acid ethyl ester

DIBAL-H

→

(5-methyl-2-naphthalen-1-yl-3H-imidazol-4-yl)-methanol

المذيبات

THF

ظروف التفاعل

المعالجة

1. 1
   أخرىquenched with brine
2. 2
   أخرىThe THF layer is separated
3. 3
   أخرىevaporated
4. 4
   workup.DISSOLUTIONThe residue is dissolved in EtOAc
5. 5
   غسيلwashed with water and brine
6. 6
   أخرىdried
7. 7
   أخرىsolvent evaporated

الإجراء التجريبي

To a solution of 5-methyl-2-naphthalen-1-yl-3H-imidazole-4-carboxylic acid ethyl ester (280 mg) in THF (8 ml) is added DIBAL-H (3.3 ml, 1.5 M in toluene) at 0° C. The resulting solution is stirred at rt for 2 hr, and quenched with brine. The THF layer is separated and then evaporated. The residue is dissolved in EtOAc, washed with water and brine, dried and solvent evaporated to afford (5-methyl-2-naphthalen-1-yl-3H-imidazol-4-yl)-methanol.

المصدر