تفاعل #40743

معادلة التفاعل

THF

5-Chloro-3-ethyl-2-naphthalen-1-yl-3H-imidazole-4-carboxylic acid ethyl ester

THF

lithium hydroxide

→

title compound

5-chloro-3-ethyl-2-naphthalen-1-yl-3H-imidazole-4-carboxylic acid

المذيبات

water

ظروف التفاعل

المعالجة

1. 1
   أخرىThe solid precipitate is collected
2. 2
   غسيلwashed with water and ether
3. 3
   أخرىdried under high vacuum

الإجراء التجريبي

5-Chloro-3-ethyl-2-naphthalen-1-yl-3H-imidazole-4-carboxylic acid ethyl ester (62 g, 35 mmol) is dissolved in. THF (10 ml), and aqueous lithium hydroxide solution (2.0 N, 6.35 ml, 2.0 eq.) is added. The mixture is heated at 50° C. overnight. THF is stripped off under reduced pressure, and the residue is diluted with water (10 ml) and basified to pH=4=5. The solid precipitate is collected, washed with water and ether, and dried under high vacuum to give the title compound. LCMS 301 (M+1).

المصدر