تفاعل #40718

معادلة التفاعل

water

1-(5-Chloro-2,4-dimethoxy-phenyl)-5-(4-fluoro-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid

acetic acid

acetic anhydride

→

1-(2,4-Dihydroxy-phenyl)-5-(4-fluoro-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid

المذيبات

hydroiodic acid

ظروف التفاعل

المعالجة

1. 1
   درجة الحرارةWhen cooled
2. 2
   استخلاصthe aqueous layer was extracted with EtOAc (2×15 mL)
3. 3
   غسيلThe combined organic layers were washed with saturated sodium thiosulphate solution (2×15 mL) and brine (20 mL)
4. 4
   تجفيفdried with NaSO4
5. 5
   ترشيحfiltered
6. 6
   أخرىAfter evaporation of the solvent
7. 7
   أخرىlight brown solids were obtained (0.15 g, 62%)
8. 8
   أخرىThe compound was used in the next synthetic step without further purification

الإجراء التجريبي

1-(5-Chloro-2,4-dimethoxy-phenyl)-5-(4-fluoro-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid (0.29 g, 0.77 mmol) was refluxed in a mixture of hydroiodic acid (5 mL), acetic acid (1 mL) and acetic anhydride (0.5 mL) for 16 hours. When cooled, water (20 mL) was added and the aqueous layer was extracted with EtOAc (2×15 mL). The combined organic layers were washed with saturated sodium thiosulphate solution (2×15 mL) and brine (20 mL), dried with NaSO4 and filtered. After evaporation of the solvent, light brown solids were obtained (0.15 g, 62%). The compound was used in the next synthetic step without further purification.

المصدر