تفاعل #40717

معادلة التفاعل

1-Azido-5-chloro-2,4-dimethoxy-benzene

3-(4-Fluoro-phenyl)-3-oxo-propionic acid methyl ester

sodium ethoxide

→

1-(5-Chloro-2,4-dimethoxy-phenyl)-5-(4-fluoro-phenyl)-1H-[1,2,3]triazole-4-carboxylic acid

المذيبات

EtOH

ظروف التفاعل

المعالجة

1. 1
   أخرىDuring the reaction
2. 2
   أخرىAfter that, EtOH was evaporated off
3. 3
   أخرىthe resulting oil was dried in vacuum
4. 4
   أخرىTrituration with ether (15 mL) gave light brown solids, which
5. 5
   أخرىwere removed by filtration
6. 6
   غسيلwashed with ether
7. 7
   workup.DISSOLUTIONThe solids then re-dissolved in CHCl3
8. 8
   ترشيحfiltered
9. 9
   أخرىAfter evaporation of the solvent
10. 10
    أخرىlight brown solids were obtained (0.35 g, 50%)

الإجراء التجريبي

1-Azido-5-chloro-2,4-dimethoxy-benzene (0.4 g, 1.9 mmol), 3-(4-Fluoro-phenyl)-3-oxo-propionic acid methyl ester (0.42 g, 2.2 mmol) and sodium ethoxide in EtOH (70 mg of sodium in 15 mL EtOH) were refluxed for 3 hours. During the reaction, the solution turned brown from dark green. After that, EtOH was evaporated off and the resulting oil was dried in vacuum. Trituration with ether (15 mL) gave light brown solids, which were removed by filtration and washed with ether. The solids then re-dissolved in CHCl3 and filtered. After evaporation of the solvent, light brown solids were obtained (0.35 g, 50%).

المصدر